Making raspberry ketone

wizardfusion

Also. Extra smelly, eh?? I can recommend: 3-Hydroxy-3-methylhexanoic acid - CAS 58888-76-9 Body odor at it's finest! YOUCH!

wizardfusion

Wow! Such an awesome video! I really like the ones that I have a previous understanding of/relationship with. I know what raspberries smell like, so hearing your perceptions when you test is intriguing and something I can use to contrast with my own reference.

Grapefruit mercaptan seems interesting, a thiol with a pleasant odor. I'm not sure about the synthesis, but one of the precursors may smell charachertisticslly sulfurous, satisfying your love of awful odors 😛

I noticed you used rubbing alcohol as solvent to make your perfume. Isn't it usually denaturated? I tried to use it once and it resulted in some additional nasty smell - I suppose that of acetone, which was clearly there.

Silviu T

I believe the meaning of "tar" here is "gooey sticky useless junk"

Paul Grodt

Are you using the terms "polymerized junk" and "tar" interchangeably? Or is there a reaction that I missed? If they are the same product, is the substance actually close to coal-tar or pine-tar, or is that just a shorthand word?

Max Goldstein

The worst smelling thing imaginable? Are you going to do selenophenol?

SadeN.moe

Given how the ketone alone in the end didn't have a very strong scent at all, I'm now wondering if a Soxhlet extraction of dried raspberries with a suitable solvent would produce a more "full" range of raspberry scent, even if the yield is relatively terrible..? It's certainly much simpler, and this actually seems like a pretty costly and labor-intensive synthesis too given the 4-hydroxybenzaldehyde and Pd/C, plus the risk of explosion/fire at two different points isn't great for a home chemist without a real, protective fume hood. :)

Yep we used spinach in our class

Joshua Pedrick

Curious what the equivalent would smell like with 4-Hydroxy-1-Napthaldehyde

Silviu T

I forgot to comment on the TLC. I know what it is and how it works having used it myself. But it may be a bit esoteric for a large part of the audience especially when the video makes it to YT so I guess you'll have to make a separate video about TLC. Or maybe about chromatography in general. Raw chlorophyll makes a good demonstration subject.

Nile Red

interesting idea

Nile Red

oooo cucumber sounds really nice. Also, for sure, ill message you now

Great video! When I have these Phenol impurities, an Acetone (sometimes together with DCM) recrystallization always helped! Or washing it with a dil. Sodium carbonate solution.

Dustin Hof

I can confirm that the smell of raspberry ketone is indeed weak and not very raspberry-like. So you're not partially anosmic to it. I was rather disappointed when I smelled it for the first time. For something stronger you might try to make (E)-2-nonenal (cucumber). Puke is rather simple, a mix of propanal and mainly propanoic acid. (In case you'd need some intermediate amateur perfumer's advice, just hit me up.)

Silviu T

Yes I've read that it can be reused a few times. I've never used it personally so I have no first-hand experience at reusing it.

Silviu T

At 13:23 in the video you say that sodium acetate isn't soluble in sodium acetate, whereas I'm sure you meant to say that it isn't soluble in ethyl acetate.

I feel like I remember from chemistry that the palladium-carbon can be reused? Is that correct?

Alf-Marius Dahl Bysveen

I just love it! And I mean all of it! <3 I really do looking forward to future parfumes. :)

Nile Red

Unfortunately, when videos get super long like this one, there just isnt space to put it :(

Nile Red

Yeah, ill fix that in the final version

Nile Red

thanks!

Nile Red

You are right! Ill have to fix that!!

Nile Red

I re-filmed the intro part of the audio to make it less jarring. For 3:05, it was definitely an error in text, so i fixed it. For 4:30, it looks okay to me. Im not sure what the error might be.

At about 3:08 you have a graphic in the upper left that says "3 ml" but you say (and clearly do add) 40ml of acetone.

Will Latinette

I like all your videos- don't worry too much about the audio quality. It's usually great but as long as you can be understood is fine. I like it when you explain the stoichiometry or just present equations a bit more- but I understand it's a pain to do. Everything you do brings back my old 'lab days'... :-)

Re:audio, I don't think the sections sound bad, per se, but there's definitely a conspicuous difference in sound whenever you switch that distracts from the narration for a moment. 3:05 Discrepancy between audio and amount displayed on-screen. 4:30 Not sure how generous your "about" is there, but probably worth checking. Either way, thanks for this video! It was very entertaining.

parcel_ch

Hi at 13:24 i think you said sodium acetate when you meant to say ethyl acetate, also yea the audio seems fine

Daniel Blake Shoemaker

I even tried Storax it smells like Candy, cinnamon, and flowers in ethanol threw distillation (Reflux) which is quite an unique smell.

Nile Red

You were trying to extract the aroma of the juice?

Nile Red

What combined to make the vomit smell?

Nile Red

yeah, its exactly the same.

The audio seems ok to me. Have you tried smelling/tasting the pills you used as the reference sample?

The audios seemed fine to me. Great overall video. Thanks

Daniel Blake Shoemaker

It sort of worked there was a trace amount of sugar left when refluxing it.

Daniel Blake Shoemaker

Yep, Red Nile I tried fruit punch in ethanol and then recrystallizing the sugar in -10 deg C for Aromas. Then I centrifgued it to get rid of any dissolved sugars. I had 70 percent ethanol for that.

Daniel Blake Shoemaker

One of my fav things to do in my lab with distillation is to make Perfumes and Aromas.

Daniel Blake Shoemaker

Hey Red Nile I often make Aromas and Perfumes. With black berries and St-johns wart I made a artifical vomit smell once. I also made weird pine smell aromas! I like mixing different materials like Storax.